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FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
October 2002
October 2002
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Abstract
The novel immunomodulator FTY720 is remarkably effective in models of transplantation
and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four
sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors
leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away
from inflammatory lesions and graft sites.