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      Quasispecies in wild-type tula hantavirus populations.

      Journal of Biology
      Animals, Arvicolinae, virology, Evolution, Molecular, Hantavirus, genetics, Mutagenesis, Nucleocapsid, RNA, Viral, analysis

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          Abstract

          Tula virus (TUL) is a recently detected hantavirus carried by European common voles. Reverse transcriptase PCR cloning was used to study TUL S segment/N protein quasispecies. Both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. At least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in TUL evolution in its natural host.

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          Author and article information

          Journal
          8971044
          191012

          Chemistry
          Animals,Arvicolinae,virology,Evolution, Molecular,Hantavirus,genetics,Mutagenesis,Nucleocapsid,RNA, Viral,analysis

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