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      Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

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          Abstract

          Background and aims

          The clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.

          Methods

          This study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.

          Results

          We identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.

          Discussion and conclusions

          The results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

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          Author and article information

          Contributors
          Journal
          2006
          Journal of Behavioral Addictions
          J Behav Addict
          Akadémiai Kiadó (Budapest )
          2062-5871
          2063-5303
          11 September 2020
          Affiliations
          [1 ] Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine , Seoul, 03722, South Korea
          [2 ] Institute of Behavioral Science in Medicine, Yonsei University College of Medicine , Seoul, 03722, South Korea
          [3 ] Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine , Seoul, 16995, South Korea
          Author notes
          []Corresponding author. eugenejung@ 123456yuhs.ac
          Article
          10.1556/2006.2020.00060
          © 2020 The Author(s)

          Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

          Page count
          Figures: 2, Tables: 1, Equations: 0, References: 53, Pages: 09
          Funding
          Funded by: Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea
          Award ID: HM14C2578
          Categories
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