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      Effects of treatment with antimicrobial agents on the human colonic microflora

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          Abstract

          Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mechanisms provided by the colonic microbial ecosystem, making the host vulnerable to infection by commensal microorganisms or nosocomial pathogens. In this minireview, the impacts of antimicrobials, individually and in combinations, on the human colonic microflora are discussed.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          December 2008
          December 2008
          : 4
          : 6
          : 1343-1358
          Affiliations
          Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR, USA
          Author notes
          Correspondence: Fatemeh Rafii, Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 71602, USA, Tel +1 870 543 7342, Fax +1 870 543 7307, Email fatemeh.rafii@ 123456fda.hhs.gov
          Article
          tcrm-4-1343
          2643114
          19337440
          © 2008 Dove Medical Press Limited. All rights reserved
          Categories
          Review

          Medicine

          intestinal bacteria, antibiotics

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