5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      New insights into the epidemiology of childhood atopic dermatitis.

      Allergy
      Child, Dermatitis, Atopic, epidemiology, etiology, Environment, Gene-Environment Interaction, Global Health, Humans, Prevalence, Risk Factors

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis (AD). Trend data on the burden of AD suggest that the picture in the developing world may soon resemble that of wealthier nations, where AD affects over 20% of children. This, combined with significant variations in prevalence within countries, emphasizes the importance of environmental factors. Many hypotheses have been explored, from the modulation of immune priming by hygiene, gut microbiota diversity, and exposure to endotoxins through farm animals to the effects of pollution, climate, and diet. The discovery of the filaggrin skin barrier gene and its importance in AD development and severity has brought the focus on gene-environment interactions and the identification of environmental factors that impact on skin barrier function. This article reviews our current understanding of the epidemiology of AD, with an emphasis on the findings reported in the international literature over the last 5 years. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

          Related collections

          Author and article information

          Journal
          24417229
          10.1111/all.12270

          Chemistry
          Child,Dermatitis, Atopic,epidemiology,etiology,Environment,Gene-Environment Interaction,Global Health,Humans,Prevalence,Risk Factors

          Comments

          Comment on this article