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      The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

      Proceedings of the National Academy of Sciences of the United States of America

      Adult, Aging, metabolism, Alzheimer Disease, Amino Acid Sequence, Animals, Brain, enzymology, Cerebral Cortex, growth & development, Fetus, Humans, Infant, Newborn, Mutagenesis, Site-Directed, Phosphorylation, Protein Kinases, Rats, Recombinant Proteins, Restriction Mapping, Serine, tau Proteins, genetics

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          Abstract

          Tau is a neuronal phosphoprotein whose expression is developmentally regulated. A single tau isoform is expressed in fetal human brain but six isoforms are expressed in adult brain, with the fetal isoform corresponding to the shortest of the adult isoforms. Phosphorylation of tau is also developmentally regulated, as fetal tau is phosphorylated at more sites than adult tau. In Alzheimer disease, the six adult tau isoforms become abnormally phosphorylated and form the paired helical filament, the major fibrous component of the characteristic neurofibrillary lesions. We show here that Ser-202 (in the numbering of the longest human brain tau isoform) is a phosphorylation site that distinguishes fetal from adult tau and we identify it as one of the abnormal phosphorylation sites in Alzheimer disease. The abnormal phosphorylation of tau at Ser-202 in Alzheimer disease thus recapitulates normal phosphorylation during development.

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          8506352
          46655

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