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      Colloidal Carbon as a Combined Ophthalmoscopic and Microscopic Probe of Retinal and Choroidal Vascular Integrity (With 1 color plate)

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          Abstract

          While studying an experimental retinal immunopathy, we searched for a vascular tracer that would permit us to test the anatomical and functional status of retinal and choroidal vessels by ophthalmoscopy, light microscopy, and electron microscopy in the same eye. We found that colloidal carbon, administered intravenously, can be seen ophthal-moscopically in the choroidal and retinal circulations, and abnormal deposits of it can be visualized in vivo. The ophthalmoscopic findings can be corroborated and extended by stereomicroscopy, and later the same specimens can be used for light and transmission electron microscopical studies. This tracer, thus, would allow the correlation of the ophthalmoscopic appearance of a clinical lesion with its histological and ultrastructural substrata.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1985
          1985
          04 December 2009
          : 17
          : 1
          : 34-41
          Affiliations
          Center for Brain Research, University of Rochester Medical Center, Rochester, N. Y., USA
          Article
          265347 Ophthalmic Res 1985;17:34–41
          10.1159/000265347
          3982782
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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