For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
7
views
27
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      356
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

          Related collections

          Most cited references27

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Effect of microporosity on scaffolds for bone tissue engineering

          Ke Zhang, Yubo Fan, Nicholas Dunne … (2018)
          Abstract Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue engineering. Although the exact mechanism, by which it promotes new bone formation, is not well recognized yet, the related hypothesis can be found in many previous studies. This review presents those possible mechanisms about how the microporosity enhances the osteogenic-related functions of cells in vitro and the osteogenic activity of scaffolds in vivo. In summary, the increased specific surface areas by microporosity can offer more protein adsorption sites and accelerate the release of degradation products, which facilitate the interactions between scaffolds and cells. Meanwhile, the unique surface properties of microporous scaffolds have a considerable effect on the protein adsorption. Moreover, capillary force generated by the microporosity can improve the attachment of bone-related cells on the scaffolds surface, and even make the cells achieve penetration into the micropores smaller than them. This review also pays attention to the relationship between the biological and mechanical properties of microporous scaffolds. Although lots of achievements have been obtained, there is still a lot of work to do, some of which has been proposed in the conclusions and perspectives part.
          Article 0 comments Cited 95 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Development of a novel bone grafting material using autogenous teeth.

            Young-Kyun Kim, Su-Gwan Kim, Ju-Hee Byeon … (2010)
            We developed a novel bone grafting material that incorporates autogenous teeth (AutoBT), and provided the basis for its clinical application. AutoBT contains organic and inorganic mineral components and is prepared from autogenous grafting material, thus eliminating the risk of an immune reaction that may lead to rejection. AutoBT was used at the time of implant placement, simultaneously with osteoinduction surgery, and excellent bony healing by osteoinduction and osteoconduction was confirmed. Crown Copyright 2010. Published by Mosby, Inc. All rights reserved.
            Article 0 comments Cited 70 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft).

              Jeffrey M Badura, S Peckham, Donald McKay (2007)
              The combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an absorbable collagen sponge (ACS) carrier has been shown to induce bone formation in a number of preclinical and clinical investigations. In 2002, rhBMP-2/ACS at a 1.5-mg/cc concentration (INFUSE Bone Graft, Medtronic Spinal and Biologics, Memphis, TN) was FDA-approved as an autograft replacement for certain interbody spinal fusion procedures. In 2004, INFUSE Bone Graft was approved for open tibial fractures with an intermedullary (IM) nail fixation. Most recently, in March 2007, INFUSE Bone Graft was approved as an alternative to autogenous bone grafts for sinus augmentations, and for localised alveolar ridge augmentations for defects associated with extraction sockets. The culmination of extensive preclinical and clinical research and three FDA approvals makes rhBMP-2 one of the most studied, published and significant advances in orthopaedics. This review article summarises a number of clinical findings of rhBMP-2/ACS, including the FDA-approved investigational device exemption (IDE) studies used in gaining the aforementioned approvals.
              Article 0 comments Cited 66 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Eui-Seok Lee:
                ORCID: https://orcid.org/0000-0002-1818-1140
                Journal
                Journal ID (nlm-ta): Scanning
                Journal ID (iso-abbrev): Scanning
                Journal ID (publisher-id): SCANNING
                Title: Scanning
                Publisher: Hindawi
                ISSN (Print): 0161-0457
                ISSN (Electronic): 1932-8745
                Publication date Collection: 2021
                Publication date (Electronic): 10 May 2021
                Volume: 2021
                Electronic Location Identifier: 6690221
                Affiliations
                1Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University Guro Hospital, Seoul 08308, Republic of Korea
                2The CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong271016, China
                Author notes

                Academic Editor: Guanghai Jin

                Author information
                https://orcid.org/0000-0001-6767-7583
                https://orcid.org/0000-0002-7281-229X
                https://orcid.org/0000-0002-8493-4657
                https://orcid.org/0000-0002-1818-1140
                Article
                DOI: 10.1155/2021/6690221
                PMC ID: 8131161
                SO-VID: 5621126a-bcfb-4041-90f3-a0bfac711c15
                Copyright © Copyright © 2021 Puneet Wadhwa et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 18 November 2020
                Date revision received : 6 April 2021
                Date accepted : 16 April 2021
                Funding
                Funded by: Korea University
                Categories
                Subject: Research Article

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content356

                See all similar

                Cited by2

                See all cited by

                Most referenced authors260

                See all reference authors