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Sudden blast crisis in patients with Philadelphia chromosome-positive chronic myeloid leukemia who achieved complete cytogenetic remission after imatinib therapy.
Giuliana Alimena
1 ,
Massimo Breccia ,
Roberto Latagliata ,
Ida Carmosino ,
Eleonora Russo ,
Francesca Biondo ,
Daniela Diverio ,
Marco Mancini ,
Mauro Nanni ,
Franco Mandelli
Sep 01 2006
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Abstract
Most patients with Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) in chronic phase (CP) who receive treatment with imatinib achieve complete cytogenetic remission (CCR), which is correlated tightly with long-term progression-free survival. In these patients, the occurrence of blastic crisis (BC) is rare, and its clinical biologic characteristics are not well known.