10
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Therapeutic Effect of Synbiotics on Chronic Functional Constipation and the Intestinal Flora Structure

      research-article

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objective: To investigate the clinical efficacy of synbiotics in the treatment of chronic functional constipation (CFC) and changes to intestinal flora before and after treatment.

          Methods: Twenty-four patients with CFC who attended the Shanghai Tenth People's Hospital, Tongji University, between July 2016 and March 2017 were selected as study subjects. Fresh stool samples were collected from the before and after one month of synbiotics treatment. The samples were tested using 16S rRNA bacterial detection technology to identify intestinal flora. A differential analysis of flora before and after treatment was conducted. Bowel habits and complications were compared before and after treatment.

          Results: After 1 month of synbiotic treatment, the frequency of defecation was significantly higher than before treatment, with fewer complications such as abdominal distension, loss of appetite, anxiety, laxative dependence. The intestinal microbiota of CFC patients was significantly altered at the genus level after treatment. In detail, the abundance of Faecalibacterium, Prevotella_9, Subdoligranulum, Ruminococcaceae_UCG-002, Bacillus, Roseburia, Pseudobutyrivibrio, Enterobacteriaceae _unclassified, Ruminococcaceae_UCG-014 and Eubacterium coprostanoligenes was greater after treatment. Bacteroides, Christensenellaceae_R-7 group, Alistipes, Parabacteroides, Escherichia-Shigella, Blautia, Lachnoclostridium, Phascolarctobacterium, Erysipelotrichaceae_UCG-003, Ruminococcus_2 and Dialister bacteria were decreased after treatment.

          Conclusion: Synbiotic treatment increases the frequency of defecation and improves the intestinal bacteria structure in CFC patients, making it a promising therapeutic strategy.

          Related collections

          Author and article information

          Journal
          CGP
          Chinese General Practice
          Compuscript (Ireland )
          1007-9572
          15 March 2018
          15 March 2018
          : 21
          : 8
          Affiliations
          [1] 1Shanghai Tenth People's Hospital Clinical College of Anhui Medical University, Shanghai 200072, China
          [2] 2Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China
          [3] 3Research Institute for Intestinal Diseases of Tongji University School of Medicine, Shanghai 200072, China
          Author notes
          Corresponding author: QIN Huan-long, Professor, Doctoral supervisor; E-mail: qin_huanlong@126.com
          Article
          j.issn.1007-9572.2018.08.006
          10.3969/j.issn.1007-9572.2018.08.006
          56311ad2-5c78-45ac-9dad-ddfddc11eedf
          © 2018 Chinese General Practice

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

          History
          Categories
          Abstract

          Endocrinology & Diabetes,General medicine,Occupational & Environmental medicine,Internal medicine,Health & Social care
          Constipation,Intestinal bacteria,Symptoms,Synbiotics

          Comments

          Comment on this article