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      Up-Regulation of Vasopressin mRNA in Paraventricular Hypophysiotrophic Neurons after Acute Immobilization Stress

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          Abstract

          Cellular levels of vasopressin (VP) and corticotropin-releasing factor (CRF) mRNAs were determined in the rat hypothalamic paraventricular nucleus after acute immobilization stress. Messenger RNA levels were measured by in situ hybridization histochemistry using <sup>35</sup>S-labeled synthetic DNA oligonucleotide probes and quantitative autoradiography. Analysis of histograms related to density values revealed that two hours after immobilization the average cellular VP and CRF mRNA levels were significantly increased (145 ± 30.3 and 68 ± 21.3%, respectively, above control values). Moreover, the number of VP-expressing parvicellular neurons was doubled in stressed rats relative to controls. These results indicate that single acute immobilization stress is sufficient to up-regulate VP as well as CRF mRNA production in the hypothalamic CRF-neurosecretory system.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1993
          1993
          08 April 2008
          : 58
          : 6
          : 625-629
          Affiliations
          aDepartment of Morphology, University of Geneva Medical School, and bDepartment of Psychiatry, IUPG, Geneva, Switzerland; cInstitute of Experimental Endocrinology, Slovak Academiy of Sciences, Bratislava, Slovakia; dFirst Department of Anatomy, Semmelweis University Medical School, Budapest,Hungary
          Article
          126602 Neuroendocrinology 1993;58:625–629
          10.1159/000126602
          8127391
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Regulation of Hypothalamic Neurons

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