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      The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats



      S. Karger AG

      Histamine, Histamine agonists, Adrenolytics, Cholinolytic, Corticosterone, Stress response, Rats

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          A possible interaction of central histaminergic receptors with adrenergic and cholinergic muscarinic neurons in increasing the pituitary-adrenocortical response under stress, assessed indirectly from the corticosterone concentration in blood serum, was investigated in conscious rats. All the drugs were administered intracerebroventriculary, the antagonists 15 to 30 min prior to the agonists. The histamine-induced increase in serum corticosterone levels of stressed rats was considerably antagonized by prazosin, phenoxybenzamine, phentolamine and yohimbine, α<sub>1</sub> and α<sub>2</sub>-adrenergic antagonists. These antagonists abolished or significantly attenuated the corticosterone response to 2-pyridylethylamine (PEA), an H<sub>1</sub>-receptor agonist, and to dimaprit and 4-methylhistamine(4-MeHA), H<sub>2</sub>-receptor agonists. Propranolol, a β-adrenergic blocker, did not substantially change the corticosterone response induced by histamine or histamine H<sub>1</sub>- and H<sub>2</sub>-receptor agonists. Similarly, atropine was ineffective in blocking the increase in serum corticosterone responses induced by either histamine or PEA and dimaprit in stressed rats. These results suggest that both α<sub>1</sub>- and α<sub>2</sub>-adrenergic receptors, but not β-adrenergic and cholinergic muscarinic receptors interact with central H<sub>1</sub> and H<sub>2</sub> histaminergic stimulation of the increased pituitary-adrenocortical response in stressed rats.

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          Author and article information

          S. Karger AG
          28 March 2008
          : 38
          : 6
          : 447-452
          Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
          123946 Neuroendocrinology 1984;38:447–452
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 6
          Original Paper


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