For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
18
views
65
references
 Top references
cited by
14
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      621
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Tendon pathology in hypercholesterolaemia patients: Epidemiology, pathogenesis and management

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Tendon pathology is a general term used to describe a group of musculoskeletal conditions related to tendons and surrounding structures. There is only limited evidence available regarding the exact aetiology and natural history of tendon pathology. In hypercholesterolaemia environments, lipids could accumulate within the extracellular matrix of the tendon and thus affect the mechanical properties of the tendon. Current evidence suggested that hypercholesterolaemia was an important risk factor in the development and progression of tendon pathology. The severity of hypercholesterolaemia was correlated with the severity of tendon pathology.

          The translational potential of this article: Hypercholesterolaemia lead to the structural, inflammatory and mechanical changes in tendons, which predispose hypercholesterolaemia patients to a greater risk of tendon pathology. Measurements of serum cholesterol are suggested to be performed in patients presenting with tendon pathology. The strict control of hypercholesterolaemia would mitigate the development and progression of tendon pathology.

          Related collections

          Most cited references65

          • Record: found
          • Abstract: found
          • Article: not found

          Pathogenesis of tendinopathies: inflammation or degeneration?

          Michele Abate, Karin Gravare-Silbernagel, Carl Siljeholm … (2009)
          The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies.
          Article 0 comments Cited 152 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel

            Raul D Santos, Samuel S Gidding, Robert A Hegele … (2016)
            Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to one in 300 000 individuals could be homozygous. The phenotypes of heterozygous and homozygous familial hypercholesterolaemia overlap considerably; the response to treatment is also heterogeneous. In this Review, we aim to define a phenotype for severe familial hypercholesterolaemia and identify people at highest risk for cardiovascular disease, based on the concentration of LDL cholesterol in blood and individuals' responsiveness to conventional lipid-lowering treatment. We assess the importance of molecular characterisation and define the role of other cardiovascular risk factors and advanced subclinical coronary atherosclerosis in risk stratification. Individuals with severe familial hypercholesterolaemia might benefit in particular from early and more aggressive cholesterol-lowering treatment (eg, with PCSK9 inhibitors). In addition to better tailored therapy, more precise characterisation of individuals with severe familial hypercholesterolaemia could improve resource use.
            Article 0 comments Cited 124 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment.

              Frederick J. Raal, Raul Santos (2012)
              Homozygous familial hypercholesterolemia (HoFH) is an autosomal co-dominant disease resulting from mutations in both copies of the low-density lipoprotein receptor (LDLR) gene. Mutations in 3 other associated genes, proprotein convertase subtilisin/kexin type 9, apolipoprotein B (APOB), and, more rarely, the autosomal recessive hypercholesterolemia adaptor protein, may lead to a similar phenotype with varying severity. HoFH patients have aggressive cardiovascular disease that develops from birth due to severe LDLR defects, resulting, in turn, in excess production of Apo B-containing atherogenic lipoproteins (low-density lipoprotein [LDL] and lipoprotein(a)). The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis often manifests in the first 2 decades of life. Treatment typically involves lipid-modifying medical therapy as well as mechanical removal of plasma LDL by means of apheresis. Although statins have afforded survival into the third and fourth decades of life, further therapeutic advancements currently under investigation promise hope of further improvements in survival and improved quality of life. The purpose of this review is to provide current perspectives on diagnosis and therapy in an effort to encourage early recognition and treatment of this rare but severe disease. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
              Article 0 comments Cited 86 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Jin Qu
                Journal
                Journal ID (nlm-ta): J Orthop Translat
                Journal ID (iso-abbrev): J Orthop Translat
                Title: Journal of Orthopaedic Translation
                Publisher: Chinese Speaking Orthopaedic Society
                ISSN (Print): 2214-031X
                ISSN (Electronic): 2214-0328
                Publication date PMC-release: 06 August 2018
                Publication date Collection: January 2019
                Publication date (Electronic): 06 August 2018
                Volume: 16
                Pages: 14-22
                Affiliations
                [a ]Department of Cardiovascular Disease, The Second Xiangya Hospital, Central South University, Changsha 410011, PR China
                [b ]Department of Sports Medicine, Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008, PR China
                Author notes
                [∗ ]Corresponding author. Department of Sports Medicine, Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha 410008, PR China. jinqu@ 123456outlook.com
                Article
                Publisher ID: S2214-031X(18)30081-0
                DOI: 10.1016/j.jot.2018.07.003
                PMC ID: 6350019
                PubMed ID: 30723677
                SO-VID: 569b8357-479c-4467-8174-aeeb921aa3aa
                Copyright © © 2018 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 13 May 2018
                Date revision received : 4 July 2018
                Date accepted : 12 July 2018
                Categories
                Subject: Review Article

                Keywords: epidemiology,hypercholesterolaemia,management,pathogenesis,tendon pathology
                Data availability:
                Keywords: epidemiology, hypercholesterolaemia, management, pathogenesis, tendon pathology

                Comments

                Comment on this article

                scite_

                Similar content621

                See all similar

                Cited by14

                See all cited by

                Most referenced authors673

                See all reference authors