There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The effects of prazosin and propranolol on total serum cholesterol concentration,
low-density lipoprotein and high-density lipoprotein cholesterol fractions, and serum
triglyceride concentration were compared in a crossover study in 29 patients with
mild to moderate essential hypertension. All patients received polythiazide at a constant
dose throughout control and drug treatment periods. Comparable blood pressure reduction
was achieved with prazosin (9.3 +/- 7.1 mg per day) and propranolol (183.6 +/- 154.5
mg per day). Prazosin administration was associated with a significant reduction in
the concentrations of total serum cholesterol (-5.5 percent), triglyceride (-20.0
percent), and low-density lipoprotein cholesterol (-10.1 percent). High-density lipoprotein
cholesterol concentration increased (+8.0 percent) as did the ratio high-density lipoprotein:
total cholesterol (+14.1 percent). No significant changes in any of the serum lipid
fractions were observed during propranolol administration.