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      Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression : A Multimodal, Multisite Machine Learning Analysis

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          Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk stratification tools to inform personalized functional-disability preventive strategies for individuals in at-risk and early phases of these illnesses.

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          Most cited references53

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          Stacked generalization

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            Cognitive impairment in euthymic major depressive disorder: a meta-analysis.

            There is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depressive disorder (MDD). However, the findings are somewhat inconsistent across the individual studies conducted to date. Our aim was to conduct a systematic review and meta-analysis of existing studies that have examined cognition in euthymic MDD patients. Following a systematic search across several publication databases, meta-analyses were conducted for 27 empirical studies that compared euthymic adult MDD patients (895 participants) and healthy controls (997 participants) across a range of cognitive domains. The influence of demographic variables and confounding factors, including age of onset and recurrent episodes, was examined. Compared with healthy controls, euthymic MDD patients were characterized by significantly poorer cognitive functions. However, the magnitude of observed deficits, with the exception of inhibitory control, were generally modest when late-onset cases were excuded. Late-onset cases demonstrated significantly more pronounced deficits in verbal memory, speed of information processing and some executive functions. Cognitive deficits, especially poor response inhibition, are likely to be persistent features, at least of some forms, of adult-onset MDD. More studies are necessary to examine cognitive dysfunction in remitted psychotic, melancholic and bipolar spectrum MDD. Cognitive deficits overall appear to be more common among patients with late-onset depression, supporting the theories suggesting that possible vascular and neurodegenerative factors play a role in a substantial number of these patients.
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              Is Open Access

              Development of the Default Mode and Central Executive Networks across early adolescence: A longitudinal study

              Highlights • We examined functional connectivity in Default Mode and Central Executive Networks. • We examined the development of these functional networks in a longitudinal sample. • Each network developed stronger internal connectivity from age 10 to 13. • The networks also became increasingly anticorrelated with one another over time. • IQ related to level of within-network connectivity and between-network segregation.

                Author and article information

                JAMA Psychiatry
                JAMA Psychiatry
                American Medical Association (AMA)
                November 01 2018
                November 01 2018
                : 75
                : 11
                : 1156
                [1 ]Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany
                [2 ]Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
                [3 ]School of Psychology, University of Birmingham, United Kingdom
                [4 ]Department of Psychiatry, University Psychiatric Clinic, Psychiatric University Hospital, University of Basel, Basel, Switzerland
                [5 ]Orygen, the National Centre of Excellence for Youth Mental Health, Melbourne, Australia
                [6 ]Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia
                [7 ]Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany
                [8 ]Department of Radiology, Ludwig-Maximilian-University, Munich, Germany
                [9 ]Institute of Mental Health, University of Birmingham, Birmingham, United Kingdom
                [10 ]Department of Psychiatry, University of Turku, Turku, Finland
                [11 ]Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
                [12 ]Melbourne Health, Melbourne, Australia
                [13 ]Corporate Global Research, GE Corporation, Munich, Germany
                [14 ]Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
                © 2018


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