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      Long-Term Low-Dose Glucocorticoid Therapy in Hyperandrogenized Women: Utility and Effects on Bone Mineral Content and Hypothalamic-Pituitary-Adrenocorticai Function

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          The effect of chronic low-dose glucocorticoid administration on bone mineral content and corticotrope reserve was investigated in 12 hyperandrogenized women treated with 1–6 mg oral evening doses of 16β-methylprednisone for 12–58 months. The hypothalamic-pituitary-adrenal axis was evaluated in 9 patients by a standard metyrapone test after 45–75 days off steroid therapy. All the patients had a normal rise in serum 11-deoxycortisol after metyrapone. Bone densitometry was assessed at the end of therapy using dual photon absorptiometry. No significant differences between patients and age-matched hyperandrogenic controls were found either in spine (1.048 ± 0.096 vs. 1.023 ± 0.175 g/cm<sup>2</sup>) or femoral neck (0.863 ± 0.115 vs. 0.899 ± 0.216 g/cm<sup>2</sup>), respectively. In conclusion, absence of quantitative bone mass reduction and normal corticotrope reserve were observed even after 58 months of daily steroid administration.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 35
          : 3-4
          : 142-145
          Division of Endocrinology and Medical Nuclear Center, Hospital de Clinicas José de San Martin, University of Buenos Aires and Laboratory of Metabolic Investigations 1 Buenos Aires, Argentina
          181890 Horm Res 1991;35:142–145
          © 1991 S. Karger AG, Basel

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          Pages: 4
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