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      Differences in Proliferation of Primary Cultures of Vascular Smooth Muscle Cells Taken from Male and Female Rats

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          Abstract

          Vascular smooth muscle cells from thoracic aortas of 10-week-old rats were cultured on different substrates. Cells taken from male animals proliferated more quickly than those taken from females; this was true for all substrates, but the difference was accentuated by growth on collagen membranes. The relationship between these results and the sex-linked incidence of hypertension and atherosclerosis is discussed and a model for future studies proposed.

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          Author and article information

          Journal
          Journal ID (publisher-id): JVR
          Journal ID (nlm-ta): J Vasc Res
          Journal ID (doi): 10.1159/issn.1018-1172
          Title: Journal of Vascular Research
          Publisher: S. Karger AG
          ISSN (Print): 1018-1172
          ISSN (Electronic): 1423-0135
          Publication date Subscription-year: 1980
          Publication date (Print): 1980
          Publication date (Electronic): 19 September 2008
          Volume: 17
          Issue: 2
          Pages: 110-116
          Affiliations
          Department of Anatomy and Embryology, University College London, London
          Article
          Publisher ID: 158240 Other ID: Blood Vessels 1980;17:110–116
          DOI: 10.1159/000158240
          SO-VID: 56c278e4-4078-4750-95a7-cf94fed6f730
          Copyright © © 1980 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 12 March 1979
          Date accepted : 15 October 1979
          Page count
          Pages: 7
          Categories
          Subject: Research Paper

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Primary cultures,Proliferation,Sex-related differences,Vascular smooth muscle
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Primary cultures, Proliferation, Sex-related differences, Vascular smooth muscle

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