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      Effect of a Hemodialysis Session on Plasma Levels of Endothelin-1 in Hypertensive and Normotensive Subjects with End-Stage Renal Failure

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          Background: Elevated plasma endothelin-1 (ET-1) was found in end-stage renal failure (ESRF). However, there are discordant reports on the influence of hypertension on plasma ET-1 in ESRF and on the effect of hemodialysis on ET-1 concentrations. Aim: To compare the time course of plasma ET-1 during hemodialysis in hypertensive (HT) and normotensive (NT) ESRF patients. Methods: Plasma ET-1 and mean blood pressure (MP) were measured in 12 HT patients and 11 matched NT patients on maintenance hemodialysis at baseline (B), after a 2.5–3.5 h hemodialysis with ultrafiltration (P1) and after a subsequent 1 h isovolumic dialysis (P2). Results: In HT patients, plasma ET-1 increased at P1 with no further change after P2 (B vs. P1 and P2, p < 0.05). In NT patients, ET-1 levels were similar at B, P1 and P2. In HT, but not in NT subjects, volume loss correlated with change of ET-1 at P1. In HT patients, MP fell during P1 and tended to return towards baseline at P2. In NT patients, MP dropped after P1 and remained lower also at P2. Conclusion: Hypertensive ESRF subjects exhibit potentiated ET-1 release on hemodialysis, possibly stimulated by volume depletion with sympathetic activation, which may attenuate hypotensive hemodialysis effects thus contributing to hypertension in ESRF.

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          Author and article information

          S. Karger AG
          13 January 1999
          : 81
          : 1
          : 31-36
          aChair and Department of Nephrology and bDepartment of Cardiology, Jagiellonian University, Cracow, cDepartment of Clinical Pharmacology, Silesian University School of Medicine, Katowice, Poland
          45242 Nephron 1999;81:31–36
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 1, Tables: 1, References: 42, Pages: 6
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          Original Paper

          Cardiovascular Medicine, Nephrology

          Hemodialysis, Endothelin, Hypertension, Chronic renal failure


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