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Behavioral state-dependent lateralization of dorsal dentate gyrus c-Fos expression in mice

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      Abstract

      Hemispheric lateralization is a fundamental organizing principle of nervous systems across taxonomic groups with bilateral symmetry. The mammalian hippocampus is lateralized anatomically, physiologically, and chemically; however, functional asymmetries are not yet well understood. Imaging studies in humans have implicated the left and right hippocampus in specialized processing. However, it is not clear if lateralized activity occurs in the rodent hippocampus. c-Fos imaging in animals provides a measure of neuronal activity with a resolution at the level of single cells. The aim of the present study was to determine whether lateralized activity-dependent c-Fos expression occurs in the rodent hippocampus. To understand functional lateralization of hippocampal processing, we compared interhemispheric expression of c-Fos in the dentate gyrus (DG), a structure involved in encoding new experiences, in mice that ran on a wheel, encoded a novel object, or remained in home cages. We found that wheel running (WR) induced the greatest amount of DG c-Fos expression in both hemispheres, with no difference between hemispheres. Object exploration (OB) resulted in left-lateralized DG c-Fos expression, whereas control (CON) mice were not lateralized. We then sought to determine whether differential consideration of hemispheres might influence the conclusions of a study by simulating common cell quantitation methods. We found that different approaches led to different conclusions. These data demonstrate lateralization of neuronal activity in the mouse DG corresponding to the experience of the animal and show that differentially considering hemisphere leads to alternative conclusions.

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      Knowing where and getting there: a human navigation network.

      The neural basis of navigation by humans was investigated with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town. Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between them. Getting to those places quickly was strongly associated with activation of the right caudate nucleus. These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigation. These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals.
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        Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.

        The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on their position along the dorsoventral axis of the hippocampus, DG granule cells (GCs) control specific features of anxiety and contextual learning. Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories. In contrast, elevating the activity of GCs in the ventral DG has no effect on contextual learning but powerfully suppresses innate anxiety. These results suggest that strategies aimed at modulating the excitability of the ventral DG may be beneficial for the treatment of anxiety disorders. Copyright © 2013 Elsevier Inc. All rights reserved.
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          The Human Hippocampus and Spatial and Episodic Memory

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            Author and article information

            Affiliations
            [1 ]Biology PhD Program, The Graduate Center, CUNY, New York, NY 11016, U.S.A.
            [2 ]CUNY Neuroscience Collaborative, The Graduate Center, CUNY, New York, NY 11016, U.S.A.
            [3 ]Psychology PhD Program, The Graduate Center, CUNY, New York, NY 11016, U.S.A.
            [4 ]Psychology Department, Queens College, CUNY, Flushing, NY 11367, U.S.A.
            Author notes
            Correspondence: Jake T. Jordan ( jake.jordan@ 123456qc.cuny.edu )
            Journal
            ppneurosig
            NS
            Neuronal Signal.
            Neuronal Signaling
            Neuronal Signal.
            Portland Press Ltd.
            2059-6553
            18 February 2019
            27 February 2019
            29 March 2019
            : 3
            : 1
            10.1042/NS20180206
            © 2019 The Author(s).

            This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).

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            Pages: 9
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            Self URI (journal page): http://www.neuronalsignaling.org/
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            Research Article
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