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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Author(s): Roberta Lazzari, E Borghesio, K Peltekian, Xiangdong Liu, K Siminovitch, Cleofe Prisco, P Almasio, Silvia Colombo, Savino Bruno, Russell Shigeta, Yan Lu, Kathy E Heathcote, Fabio Macciardi, Roman Kosoy, Paolo Muratori, Carlo Ferrari, Luca Fabris, Giancarlo Spinzi, Barbara Agata Coco, Pier Margotti, Cameron Ghent, Mauro Podda, Rou-Gang Xie, Piero Portincasa, Maria Grazia Niro, Michael Myers, Maria C Bragazzi, Lorenzo Morini, Sara Lupoli, Massimo Colombo, Claudio Tiribelli, Floriano Rosina, Andrea Galli, Carlo Selmi, Antonio Benedetti, Agostino Colli, Annarosa Floreani, O Palmieri, Domenico Alvaro, Massimo Zuin, Pietro Invernizzi, Maurizia Brunetto, Fabio Marra, Ilaria Bianchi, Giovanni Casella, Marco Marzioni, Michael Ransom, M. Gershwin, Yue M. Lu, Cristina Rigamonti, Belinda Lee, Francesca Bernuzzi, Alberto Mattalia, Sonia Rossi, A Pisano, Pietro Andreone, Christopher Amos, Pierluigi Toniutto, K. Gregersen, CHUN XU, Michael F. Seldin, Angelo Andriulli, Luigi Muratori, Lory Saveria Crocé, Nicola Caporaso, Renzo Montanari, Sarah L. Mason, Ana Lleo, Gideon Hirschfield, Antonio Picciotto, Mario Strazzabosco, Maria Cristina Vinci

Publication date: 2010-07-31

Journal: Nature genetics

Keywords: genetics, Alleles, Odds Ratio, Canada, Humans, European Continental Ancestry Group, Interferon Regulatory Factors, Meta-Analysis as Topic, Liver Cirrhosis, Biliary, Genome, Genome-Wide Association Study

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Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

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DOI:: 10.1038/ng.627

PMC ID:: 3150510

PubMed ID:: 20639880

ScienceOpen disciplines: Chemistry

Keywords: genetics,Alleles,Odds Ratio,Canada,Humans,European Continental Ancestry Group,Interferon Regulatory Factors,Meta-Analysis as Topic,Liver Cirrhosis, Biliary,Genome,Genome-Wide Association Study

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ScienceOpen disciplines: Chemistry

Keywords: genetics, Alleles, Odds Ratio, Canada, Humans, European Continental Ancestry Group, Interferon Regulatory Factors, Meta-Analysis as Topic, Liver Cirrhosis, Biliary, Genome, Genome-Wide Association Study

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