This study investigated whether the adoption of electronic prescriptions (e-prescriptions) had increased in the 27 member countries of the European Union (EU) in the beginning of this decade. Our previous study in 2002 concerning the old union with 15 countries had discovered that e-prescriptions were rare in daily practice and that there was only slight interest for their future use. Since the internal market with free movement of people, goods, services, and capital is a central issue in the Union, we took a cross-border view of the use of the e-prescriptions.