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      TGF-beta signal transduction.

      Annual review of biochemistry

      metabolism, classification, Transforming Growth Factor beta, Trans-Activators, Smad1 Protein, Signal Transduction, Receptors, Transforming Growth Factor beta, Protein-Serine-Threonine Kinases, genetics, etiology, Neoplasms, Humans, Genetic Diseases, Inborn, Gene Expression Regulation, DNA-Binding Proteins, Biological Transport

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          Abstract

          The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.

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          Author and article information

          Journal
          10.1146/annurev.biochem.67.1.753
          9759503

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