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      Larvicidal Potential of Caribbean Plants

      review-article
      1 , 1 , 2 ,
      BioMed Research International
      Hindawi

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          Abstract

          Mosquitoes are vectors for numerous arboviruses such as dengue, chikungunya, and Zika which continue to negatively impact the health of Caribbean populations. Within the region, synthetic insecticides are primarily used to control mosquito populations. In many countries however, these compounds are becoming less effective due to resistance, and they may also be harmful to the environment. Thus, there is a significant need for the development of alternative agents to combat the mosquito threat in the Caribbean. Worldwide, botanical-based products are being increasingly investigated for vector control because they are environmentally friendly and are often highly effective mosquitocidal agents. Although the botanical diversity within the Caribbean is remarkable, work on plant biopesticides in the region remains limited. The aim of this review, therefore, is to discuss the use of Caribbean botanical extracts as larvicidal agents. Additionally, we highlight the need for future work in this area which may subsequently lead to the implementation of transformative public health policies.

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          Most cited references48

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          Mechanism of action of organophosphorus and carbamate insecticides.

          T Fukuto (1990)
          Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed.
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            Plant extracts as potential mosquito larvicides

            Mosquitoes act as a vector for most of the life threatening diseases like malaria, yellow fever, dengue fever, chikungunya ferver, filariasis, encephalitis, West Nile Virus infection, etc. Under the Integrated Mosquito Management (IMM), emphasis was given on the application of alternative strategies in mosquito control. The continuous application of synthetic insecticides causes development of resistance in vector species, biological magnification of toxic substances through the food chain and adverse effects on environmental quality and non target organisms including human health. Application of active toxic agents from plant extracts as an alternative mosquito control strategy was available from ancient times. These are non-toxic, easily available at affordable prices, biodegradable and show broad-spectrum target-specific activities against different species of vector mosquitoes. In this article, the current state of knowledge on phytochemical sources and mosquitocidal activity, their mechanism of action on target population, variation of their larvicidal activity according to mosquito species, instar specificity, polarity of solvents used during extraction, nature of active ingredient and promising advances made in biological control of mosquitoes by plant derived secondary metabolites have been reviewed.
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              Molecular Targets for Components of Essential Oils in the Insect Nervous System—A Review

              Essential oils (EOs) are lipophilic secondary metabolites obtained from plants; terpenoids represent the main components of them. A lot of studies showed neurotoxic actions of EOs. In insects, they cause paralysis followed by death. This feature let us consider components of EOs as potential bioinsecticides. The inhibition of acetylcholinesterase (AChE) is the one of the most investigated mechanisms of action in EOs. However, EOs are rather weak inhibitors of AChE. Another proposed mechanism of EO action is a positive allosteric modulation of GABA receptors (GABArs). There are several papers that prove the potentiation of GABA effect on mammalian receptors induced by EOs. In contrast, there is lack of any data concerning the binding of EO components in insects GABArs. In insects, EOs act also via the octopaminergic system. Available data show that EOs can increase the level of both cAMP and calcium in nervous cells. Moreover, some EO components compete with octopamine in binding to its receptor. Electrophysiological experiments performed on Periplaneta americana have shown similarity in the action of EO components and octopamine. This suggests that EOs can modify neuron activity by octopamine receptors. A multitude of potential targets in the insect nervous system makes EO components interesting candidates for bio-insecticides.
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                Author and article information

                Contributors
                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi
                2314-6133
                2314-6141
                2023
                26 August 2023
                : 2023
                : 5518863
                Affiliations
                1Department of Basic Medical Sciences, Pharmacology and Pharmacy Section, The University of the West Indies Mona, Kingston 7, Jamaica
                2Mosquito Control and Research Unit, The University of the West Indies, Mona, Jamaica
                Author notes

                Academic Editor: Cassiano Felippe Gonçalves-de-Albuquerque

                Author information
                https://orcid.org/0009-0001-7703-4327
                https://orcid.org/0000-0003-2368-0902
                Article
                10.1155/2023/5518863
                10474962
                37663786
                5722c264-aaea-4210-a9ed-5b53e58156be
                Copyright © 2023 Rhaheem N. A. Layne-Yarde and Simone L. Sandiford.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 February 2023
                : 12 June 2023
                : 1 August 2023
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