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      Maternal and Paternal Alcohol Consumption Increase Offspring Susceptibility to Pseudomonas aeruginosa Ocular Infection

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          Abstract

          Male rats that consumed liquid alcohol diets containing 35%, 17.5 or 0% ethanol-derived calories for a minimum of 3 weeks were bred to females which were fed similar diets during pregnancy. At approximately 50 days of age, offspring were challenged with 10 × 10<sup>7</sup> Pseudomonas aeruginosa onto the scarified cornea. The ocular response, evaluated macroscopically, for 3 weeks, revealed a significant dose-related effect of both maternal and paternal alcohol exposure. The higher the parental alcohol consumption the earlier and the more frequently the cornea of progeny perforated. There was no effect of sex of offspring or interaction between maternal and paternal factors. Histopathology confirmed the above data in that progeny of parents receiving 0% or lower-dose alcohol treatment had less severe corneal pathology than progeny of parents with higher alcohol doses

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1989
          1989
          10 December 2009
          : 21
          : 5
          : 381-387
          Affiliations
          Department of aAnatomy/Cell Biology and bImmunology/Microbiology, and cThe Fetal Alcohol Research Center, Wayne State University School of Medicine Detroit, Mich., USA
          Article
          266905 Ophthalmic Res 1989;21:381–387
          10.1159/000266905
          2513544
          573e2632-6d1c-4266-a6e0-52a41795924b
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 29 September 1988
          : 14 December 1988
          Page count
          Pages: 7
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Susceptibility,Maternal alcohol,<italic>Pseudomonas aeruginosa</italic>,Rats,Paternal alcohol,Progeny

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