Emer R. McGrath:
ORCID: http://orcid.org/0000-0002-3589-2964
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draft
Jayandra J. Himali: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole:
Writing – review & editing
Daniel Levy: Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: SupervisionRole: Writing – review & editing
Sarah C. Conner: Role: Formal analysisRole: Project administrationRole: Writing – review & editing
Matthew P. Pase: Role: InvestigationRole: Writing – review & editing
Carmela R. Abraham: Role: InvestigationRole: Writing – review & editing
Paul Courchesne: Role: InvestigationRole: Writing – review & editing
Claudia L. Satizabal:
ORCID: http://orcid.org/0000-0002-1115-4430
Role: InvestigationRole: Writing – review & editing
Ramachandran S. Vasan: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: Writing –
review & editing
Alexa S. Beiser: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Sudha Seshadri: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
SupervisionRole: Writing – review & editing
Stephen D. Ginsberg: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
4
March
2019
Publication date Collection: 2019
Volume: 14
Issue: 3
Electronic Location Identifier: e0213321
Affiliations
[1
]
Department of Neurology, Brigham & Women’s Hospital, Boston, MA, United States of
America
[2
]
Harvard Medical School, Boston, MA, United States of America
[3
]
Framingham Heart Study, Framingham, MA, United States of America
[4
]
Boston University School of Public Health, Boston, MA, United States of America
[5
]
Boston University School of Medicine, Boston, MA, United States of America
[6
]
Population Sciences Branch, National Heart, Lung and Blood Institutes of Health, Bethesda,
MD, United States of America
[7
]
Melbourne Dementia Research Centre, The Florey Institute for Neuroscience and Mental
Health, Victoria, Australia
[8
]
Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of
Texas Health Sciences Center, San Antonio, TX, United States of America
Nathan S Kline Institute, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-35509
DOI: 10.1371/journal.pone.0213321
PMC ID: 6398923
PubMed ID: 30830941
SO-VID: 57434a7d-d244-4c65-842a-d95812d7392f
Copyright © © 2019 McGrath et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
The Framingham Heart Study is supported by the National Heart, Lung, and Blood Institute
contract no. N01-HC-25195 and no. HHSN268201500001I (RSV, SS, DL) and this research
is supported by the Alzheimer’s association clinician scientist fellowship AACSF-18-566570
(ERM), NHLBI grants R01 HL60040 and R01 HL70100 (RSV, DL, SS), grants from the National
Institute on Aging R01 AG054076, R01 AG049607, R01 AG033193, U01 AG049505, U01 AG052409
(SS) and the National Institute of Neurological Disorders and Stroke NS017950 and
UH2 NS100605 (SS). Additional funding for the Systems Approach to Biomarker Research
in Cardiovascular Disease (SABRe CVD) initiative was provided by the Division of Intramural
Research, NHLBI, and the Population Sciences Branch, NHLBI (DL).
https://www.alz.org;
https://www.nia.nih.gov;
https://www.ninds.nih.gov;
https://www.nhlbi.nih.gov. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Growth Factors
Subject:
Fibroblast Growth Factor
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Growth Factors
Subject:
Fibroblast Growth Factor
Subject:
Medicine and Health Sciences
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Physiology
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Endocrine Physiology
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Growth Factors
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Fibroblast Growth Factor
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Dementia
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Medicine and Health Sciences
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Neurology
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Dementia
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Medicine and Health Sciences
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Mental Health and Psychiatry
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Dementia
Subject:
Alzheimer's Disease
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Dementia
Subject:
Alzheimer's Disease
Subject:
Medicine and Health Sciences
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Neurology
Subject:
Neurodegenerative Diseases
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Alzheimer's Disease
Subject:
Biology and Life Sciences
Subject:
Neuroscience
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Cognitive Science
Subject:
Cognitive Neuroscience
Subject:
Cognitive Neurology
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Cognitive Impairment
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Biology and Life Sciences
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Neuroscience
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Cognitive Neuroscience
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Cognitive Neurology
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Cognitive Impairment
Subject:
Medicine and Health Sciences
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Neurology
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Cognitive Neurology
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Cognitive Impairment
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Medicine and Health Sciences
Subject:
Cardiovascular Medicine
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Cardiovascular Diseases
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Physical sciences
Subject:
Chemistry
Subject:
Chemical compounds
Subject:
Organic compounds
Subject:
Vitamins
Subject:
Vitamin D
Subject:
Physical sciences
Subject:
Chemistry
Subject:
Organic chemistry
Subject:
Organic compounds
Subject:
Vitamins
Subject:
Vitamin D
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Cerebrovascular Diseases
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Vascular Dementia
Subject:
Medicine and Health Sciences
Subject:
Mental Health and Psychiatry
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Dementia
Subject:
Vascular Dementia
Subject:
Medicine and Health Sciences
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Neurology
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Dementia
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Vascular Dementia
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Vascular Medicine
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Blood Pressure
