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      Determination of Sensitivity and Specificity of the Micral-Test II Strip for Detection of Microalbuminuria in Diabetic and Nondiabetic Patients

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          Clinical significance of microalbuminuria and evaluation of the Micral-Test.

           C Hasslacher (1993)
          Microalbuminuria is defined as excretion of albumin between 20 and 200 micrograms/min. Persistent microalbuminuria indicates a high probability of damage to the glomerular filtration capacity of the kidney and is of great diagnostic relevance: (a) in diabetes, for early diagnosis of diabetic nephropathy; (b) in patients with hypertension, as an indicator of end-organ damage associated with a lowered life expectancy; (c) in pregnancy, as a possible predictor of developing preeclampsia. For screening, a concentration of 20-200 mg/L of albumin in the first morning urine has been proven to be a suitable indicator. The Micral-Test is a test strip now available that makes a semiquantitative assessment of the albumin concentration in the urine at various levels (0, 10, 20, 50, 100 mg/L). Many studies have shown that the sensitivity and specificity of the test strip is 90% or higher in urine containing elevated albumin concentrations. Furthermore, it was shown that there is no influence on the measurement from interfering factors such as glucose concentration, pH value, ketonuria, storage of the sample, or bacterial contamination in the urine. The Micral-Test offers a simple, exact, and with respect to interference effects, a robust testing method for the semiquantitative assessment of albumin concentration in the urine.
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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            1999
            April 1999
            31 March 1999
            : 81
            : 4
            : 455
            Affiliations
            aDivision of Nephrology, Department of Medicine, and bDepartment of Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
            Article
            45338 Nephron 1999;81:455
            10.1159/000045338
            10095190
            © 1999 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            References: 5, Pages: 1
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/45338
            Categories
            Letter to the Editor

            Cardiovascular Medicine, Nephrology

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