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      Icariin combined with breviscapine improves the erectile function of spontaneously hypertensive rats.

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          Abstract

          The impaired erectile response in spontaneously hypertensive rats (SHR) is caused by increased signaling of RhoA/Rho-kinase and decreased signaling of nitric oxide (NO). Icariin improves erectile function via upregulating multitargets in NO/cyclic guanosine monophosphate (NO/cGMP) pathway, which breviscapine accomplishes by downregulating RhoA/Rho-kinase pathway.

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          Author and article information

          Journal
          J Sex Med
          The journal of sexual medicine
          Wiley
          1743-6109
          1743-6095
          Sep 2014
          : 11
          : 9
          Affiliations
          [1 ] Department of Cardiovascular Diseases, Affiliated Hospital, Luzhou Medical College, Luzhou, China.
          Article
          S1743-6095(15)30841-9
          10.1111/jsm.12614
          24912989
          576bdfb6-0069-47bc-8e68-c167561d5f74
          History

          Breviscapine,Rat,Icariin,Hypertension,Erectile Function,Erectile Dysfunction

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