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      Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.

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          Abstract

          The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jan 16 1998
          : 279
          : 5349
          Affiliations
          [1 ] Department of Microbiology, Umeâ University, SE-901 87 Umeâ, Sweden.
          Article
          10.1126/science.279.5349.373
          9430586
          576d429b-d874-412d-abd3-e40bcd7ba824
          History

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