51
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

      research-article
      1 , 2 , 3 , 4 , 5 , 3 , 4 , 1 , 1 , 1 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 3 , 14 , 15 , 16 , 17 , 18 , 19 ,   20 , 9 , 21 , 9 , 9 , 22 , 20 , 23 , 24 , 25 , 12 , 26 , 20 , 16 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 17 , 27 , 35 , 36 , 37 , 38 , 39 , 40 , 35 , 33 , 34 , 41 , 42 , 3 , 43 , 3 , 44 , 18 , 45 , 46 , 47 , 31 , 48 , 49 , 50 , 51 , 35 , 33 , 52 , 14 , 48 , 53 , 54 , 23 , 55 , 56 , 32 , 8 , 57 , 9 , 10 , 25 , 32 , 29 , 30 , 58 , 38 , 39 , 20 , 38 , 39 , 33 , 59 , 33 , 34 , 33 , 34 , 60 , 29 , 30 , 8 , 61 , 35 , 8 , 28 , 62 , 11 , 13 , 63 , 64 , 42 , 65 , 66 , 67 , 38 , 39 , 33 , 26 , 33 , 34 , 66 , 67 , 33 , 34 , 68 , 14 , 69 , 7 , 16 , 51 , 14 , 70 , 71 , 26 , 9 , 72 , 12 , 13 , 63 , 60 , 26 , 13 , 73 , 33 , 74 , 26 , 72 , 38 , 39 , 18 , 25 , 68 , 75 , 17 , 76 , 77 , 17 , 33 , 78 , 79 , 3 , 19 , 1 , 3 , 4 , *
      Molecular Psychiatry
      Nature Publishing Group

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen’s d=−0.293; P=1.71 × 10 −21), left fusiform gyrus ( d=−0.288; P=8.25 × 10 −21) and left rostral middle frontal cortex ( d=−0.276; P=2.99 × 10 −19). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.

          Related collections

          Most cited references68

          • Record: found
          • Abstract: found
          • Article: not found

          Specification of cerebral cortical areas.

          P Rakic (1988)
          How the immense population of neurons that constitute the human cerebral neocortex is generated from progenitors lining the cerebral ventricle and then distributed to appropriate layers of distinctive cytoarchitectonic areas can be explained by the radial unit hypothesis. According to this hypothesis, the ependymal layer of the embryonic cerebral ventricle consists of proliferative units that provide a proto-map of prospective cytoarchitectonic areas. The output of the proliferative units is translated via glial guides to the expanding cortex in the form of ontogenetic columns, whose final number for each area can be modified through interaction with afferent input. Data obtained through various advanced neurobiological techniques, including electron microscopy, immunocytochemistry, [3H]thymidine and receptor autoradiography, retrovirus gene transfer, neural transplants, and surgical or genetic manipulation of cortical development, furnish new details about the kinetics of cell proliferation, their lineage relationships, and phenotypic expression that favor this hypothesis. The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.

            The advent of functional neuroimaging has allowed tremendous advances in our understanding of brain-language relationships, in addition to generating substantial empirical data on this subject in the form of thousands of activation peak coordinates reported in a decade of language studies. We performed a large-scale meta-analysis of this literature, aimed at defining the composition of the phonological, semantic, and sentence processing networks in the frontal, temporal, and inferior parietal regions of the left cerebral hemisphere. For each of these language components, activation peaks issued from relevant component-specific contrasts were submitted to a spatial clustering algorithm, which gathered activation peaks on the basis of their relative distance in the MNI space. From a sample of 730 activation peaks extracted from 129 scientific reports selected among 260, we isolated 30 activation clusters, defining the functional fields constituting three distributed networks of frontal and temporal areas and revealing the functional organization of the left hemisphere for language. The functional role of each activation cluster is discussed based on the nature of the tasks in which it was involved. This meta-analysis sheds light on several contemporary issues, notably on the fine-scale functional architecture of the inferior frontal gyrus for phonological and semantic processing, the evidence for an elementary audio-motor loop involved in both comprehension and production of syllables including the primary auditory areas and the motor mouth area, evidence of areas of overlap between phonological and semantic processing, in particular at the location of the selective human voice area that was the seat of partial overlap of the three language components, the evidence of a cortical area in the pars opercularis of the inferior frontal gyrus dedicated to syntactic processing and in the posterior part of the superior temporal gyrus a region selectively activated by sentence and text processing, and the hypothesis that different working memory perception-actions loops are identifiable for the different language components. These results argue for large-scale architecture networks rather than modular organization of language in the left hemisphere.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Distinct genetic influences on cortical surface area and cortical thickness.

              Neuroimaging studies examining the effects of aging and neuropsychiatric disorders on the cerebral cortex have largely been based on measures of cortical volume. Given that cortical volume is a product of thickness and surface area, it is plausible that measures of volume capture at least 2 distinct sets of genetic influences. The present study aims to examine the genetic relationships between measures of cortical surface area and thickness. Participants were men in the Vietnam Era Twin Study of Aging (110 monozygotic pairs and 92 dizygotic pairs). Mean age was 55.8 years (range: 51-59). Bivariate twin analyses were utilized in order to estimate the heritability of cortical surface area and thickness, as well as their degree of genetic overlap. Total cortical surface area and average cortical thickness were both highly heritable (0.89 and 0.81, respectively) but were essentially unrelated genetically (genetic correlation = 0.08). This pattern was similar at the lobar and regional levels of analysis. These results demonstrate that cortical volume measures combine at least 2 distinct sources of genetic influences. We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure.
                Bookmark

                Author and article information

                Journal
                Mol Psychiatry
                Mol. Psychiatry
                Molecular Psychiatry
                Nature Publishing Group
                1359-4184
                1476-5578
                April 2018
                02 May 2017
                : 23
                : 4
                : 932-942
                Affiliations
                [1 ]Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, University of Southern California , Marina del Rey, CA, USA
                [2 ]Janssen Research & Development , San Diego, CA, USA
                [3 ]NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo , Oslo, Norway
                [4 ]Division of Mental Health and Addiction, Oslo University Hospital , Oslo, Norway
                [5 ]Department of Psychology, University of Oslo , Oslo, Norway
                [6 ]Neuroscience Interdepartmental Graduate Program, University of California, Los Angeles , Los Angeles, CA, USA
                [7 ]Department of Psychiatry, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA
                [8 ]University Department of Psychiatry and Oxford Health NHS Foundation Trust, University of Oxford , Oxford, UK
                [9 ]Department of Psychiatry and Mental Health, University of Cape Town , Cape Town, South Africa
                [10 ]MRC Unit on Anxiety and Stress Disorders, Groote Schuur Hospital (J-2), University of Cape Town , Cape Town, South Africa
                [11 ]UT Center of Excellence on Mood Disorders, Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston , Houston, TX, USA
                [12 ]Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University , Heidelberg, Germany
                [13 ]Neuroscience Research Australia , Sydney, NSW, Australia
                [14 ]Department of Clinical Neuroscience, Osher Centre, Karolinska Institutet , Stockholm, Sweden
                [15 ]Department of Psychology, City University London , London, UK
                [16 ]Institute of Psychiatry, Psychology & Neuroscience, King's College London , London, UK
                [17 ]Department of Psychiatry, University of Münster , Münster, Germany
                [18 ]Department of Psychiatry, Icahn School of Medicine at Mount Sinai , New York, NY, USA
                [19 ]Department of Psychiatric Research, Diakonhjemmet Hospital , Oslo, Norway
                [20 ]Hospital Clinic, IDIBAPS, University of Barcelona, CIBERSAM , Barcelona, Spain
                [21 ]IRCCS "E. Medea" Scientific Institute, San Vito al Tagliamento , Italy
                [22 ]Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University , Providence, RI, USA
                [23 ]INSERM U955 Team 15 ‘Translational Psychiatry’, University Paris East, APHP, CHU Mondor, Fondation FondaMental , Créteil, France
                [24 ]NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay , Gif Sur Yvette, France
                [25 ]Department of Psychiatry, University of Pennsylvania , Philadelphia, PA, USA
                [26 ]Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht , Utrecht, The Netherlands
                [27 ]Department of Psychiatry and Psychotherapy, University Medical Center Göttingen , Göttingen, Germany
                [28 ]Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam , Amsterdam, The Netherlands
                [29 ]Department of Psychiatry, Yale University , New Haven, CT, USA
                [30 ]Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital , Hartford, CT, USA
                [31 ]Centre for Affective Disorders, King’s College London , London, UK
                [32 ]Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway , Galway, Ireland
                [33 ]Department of Psychiatry, Faculty of Medicine, University of São Paulo , São Paulo, Brazil
                [34 ]Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo , São Paulo, Brazil
                [35 ]Division of Psychiatry, University of Edinburgh , Edinburgh, UK
                [36 ]Department of Psychiatry, University of California, Los Angeles , Los Angeles, CA, USA
                [37 ]West Los Angeles Veterans Administration , Los Angeles, CA, USA
                [38 ]FIDMAG Germanes Hospitalàries Research Foundation , Barcelona, Spain
                [39 ]Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) , Madrid, Spain
                [40 ]Department of Psychiatry and Human Behavior, University of California , Irvine, CA, USA
                [41 ]Department of Neurosurgery, Medical College of Wisconsin , Milwaukee, WI, USA
                [42 ]Laureate Institute for Brain Research , Tulsa, OK, USA
                [43 ]Department of Neurology, Oslo University Hospital , Oslo, Norway
                [44 ]Department of Adult Psychiatry, University of Oslo , Oslo, Norway
                [45 ]Department of Psychiatry, Radboud University Medical Center , Nijmegen, The Netherlands
                [46 ]Donders Institute for Brain, Cognition and Behavior, Radboud University , Nijmegen, The Netherlands
                [47 ]Academic Psychiatry and Northern Centre for Mood Disorders, Newcastle University/Northumberland Tyne & Wear NHS Foundation Trust , Newcastle, UK
                [48 ]Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health , Bethesda, MD, USA
                [49 ]MMIL, Department of Radiology, University of California San Diego , San Diego, CA, USA
                [50 ]Department of Cognitive Science, Neurosciences and Psychiatry, University of California, San Diego , San Diego, CA, USA
                [51 ]Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden , Dresden, Germany
                [52 ]Department of Psychiatry, University of Adelaide , Adelaide, SA, Australia
                [53 ]Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA, USA
                [54 ]Department of Psychology, University of California, Los Angeles , Los Angeles, CA, USA
                [55 ]Institut Pasteur, Unité Perception et Mémoire , Paris, France
                [56 ]Bipolar Center Wiener Neustadt , Wiener Neustadt, Austria
                [57 ]Department of Psychology & Counselling, Newman University , Birmingham, UK
                [58 ]Department of Psychiatry, VU University Medical Center , Amsterdam, The Netherlands
                [59 ]Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine , Cincinnati, OH, USA
                [60 ]School of Psychiatry and Black Dog Institute, University of New South Wales , Sydney, NSW, Australia
                [61 ]Department of Clinical Radiology, University of Münster , Münster, Germany
                [62 ]Department of Psychiatry, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands
                [63 ]School of Medical Sciences, University of New South Wales , Sydney, NSW, Australia
                [64 ]Department of Adult Psychiatry, Poznan University of Medical Sciences , Poznan, Poland
                [65 ]Faculty of Community Medicine, The University of Tulsa , Tulsa, OK, USA
                [66 ]Department of Radiology, University of São Paulo , São Paulo, Brazil
                [67 ]LIM44-Laboratory of Magnetic Resonance in Neuroradiology, University of São Paulo , São Paulo, Brazil
                [68 ]Department of Psychiatry, Dalhousie University , Halifax, NS, Canada
                [69 ]Department of Neuroradiology, Karolinska University Hospital , Stockholm, Sweden
                [70 ]Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University , Goteborg, Sweden
                [71 ]Department of Psychology, University of Exeter , Exeter, UK
                [72 ]Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA, USA
                [73 ]School of Psychiatry, University of New South Wales , Sydney, NSW, Australia
                [74 ]National Institute of Mental Health, National Institutes of Health , Bethesda, MD, USA
                [75 ]National Institute of Mental Health , Klecany, Czech Republic
                [76 ]Division of Clinical Neuroscience, Department of Research and Education, Oslo University Hospital , Oslo, Norway
                [77 ]Institute of Clinical Medicine, University of Oslo , Oslo, Norway
                [78 ]Janssen Research & Development , Titusville, NJ, USA
                [79 ]MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University , Cardiff, UK
                Author notes
                [* ]NORMENT, KG Jebsen Centre for Psychosis Research—TOP Study, Oslo University Hospital , Ullevål, Building 49, Kirkeveien 166, PO Box 4956, Nydalen, 0424, Oslo, Norway. E-mail: o.a.andreassen@ 123456medisin.uio.no
                Author information
                http://orcid.org/0000-0003-3166-5606
                http://orcid.org/0000-0001-9697-8596
                http://orcid.org/0000-0002-3063-6929
                http://orcid.org/0000-0002-4349-1984
                Article
                mp201773
                10.1038/mp.2017.73
                5668195
                28461699
                577259f7-e299-49b5-aef2-6c27db20e6dc
                Copyright © 2018 The Author(s)

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

                History
                : 03 August 2016
                : 04 February 2017
                : 10 February 2017
                Categories
                Original Article

                Molecular medicine
                Molecular medicine

                Comments

                Comment on this article