175
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The widespread regulation of microRNA biogenesis, function and decay.

      Nature reviews. Genetics

      Animals, Gene Expression Regulation, Humans, MicroRNAs, genetics, metabolism, RNA Stability

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.

          Related collections

          Author and article information

          Journal
          20661255
          10.1038/nrg2843

          Chemistry

          Animals, Gene Expression Regulation, Humans, MicroRNAs, genetics, metabolism, RNA Stability

          Comments

          Comment on this article