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      Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke.

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          Abstract

          Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress.

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          Author and article information

          Journal
          J Pharmacol Sci
          Journal of pharmacological sciences
          Elsevier BV
          1347-8648
          1347-8613
          Nov 2020
          : 144
          : 3
          Affiliations
          [1 ] Laboratory of Pharmacology and Neurobiology, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan.
          [2 ] Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
          [3 ] Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8414, Japan.
          [4 ] Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu, Gifu, 501-1196, Japan.
          [5 ] Laboratory of Pharmacology and Neurobiology, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan. Electronic address: yo-kita@fc.ritsumei.ac.jp.
          Article
          S1347-8613(20)30077-3
          10.1016/j.jphs.2020.07.012
          32807663
          57765547-e377-4abb-98fe-f1d583393f9e
          Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
          History

          5-Aminolevulinic acid,Neuroprotection,Oxidative stress

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