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      Specific IgE antibodies in nasal secretions: correlation with serum values and clinical tests.

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          Abstract

          The presence of specific IgE in external secretions and the possibility of quantifying it has aroused the interest of many research workers. Nevertheless, there is still disagreement with regard to how useful this practice is from a clinical point of view. We have compared the presence of Dermatophagoides pteronyssinus (Dp) specific-IgE in the nasal secretion of 17 patients suffering from rhinitis with the results of prick tests and nasal and/or conjunctival challenge tests. As a preliminary step we have updated techniques and made a correlation between the parameters mentioned. The results for total IgE (n = 17) show a correlation coefficient (r = .39, NS) between serum values (251 +/- 239) U/L and those obtained in nasal secretion (28 +/- 36) U/L. (2) Serum and nasal-Dp-specific-IgE values (13 +/- 15 and 5 +/- 9, respectively: (r = .72, P = .0011) match in 14 of the 17 determinations. In two of them, the serum values of Dp-specific-IgE, but not the nasal ones, match the in vivo tests. In the others, it is the nasal secretion determination that matches the in vivo tests while the serum and nasal determinations match (82%). These results match in 86% of cases with prick tests and in 93% with nasal/conjunctival challenge tests.(ABSTRACT TRUNCATED AT 250 WORDS)

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          Author and article information

          Journal
          Ann Allergy
          Annals of allergy
          0003-4738
          0003-4738
          Jan 1993
          : 70
          : 1
          Affiliations
          [1 ] Allergology and Clinical Immunology Service, Val D'Hebron Children's Hospital, Barcelona, Spain.
          Article
          8424593
          57800484-83d0-44a2-86ae-76b3d1aa2e7b
          History

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