Research update on the effect of adverse childhood experience on telomere morphology

Abstract

Adverse childhood experiences (ACEs) not only affect individual’s physical and mental health but also have adverse intergenerational effects. A growing body of researches focused on biological mechanism of ACEs, among which the emerging role of telomere has gained much attention. This article reviews the association between ACEs and telomere morphology during different developmental stages and the role of telomere in adverse health effects of ACEs. It aims to summarize possible mechanisms underlying negative effects of ACEs.

Abstract

【摘要】 童年期不良经历不仅损害个体躯体和心理健康, 还可能对后代身心健康产生不良影响, 越来越多的研究开始关 注其中涉及的生物学机制, 特别是端粒在关联中的作用巳成为近年来研究的热点。研究从童年期不良经历与不同生命阶 段端粒形态的改变以及端粒在童年期不良经历与健康关联中的作用进行综述, 旨在深入认识童年期不良经历健康危害效 应的潜在机制。