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      Microvascular contrast enhancement in optical coherence tomography using microbubbles.

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          Abstract

          Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation times and higher structural and svOCT image contrasts were detected in the presence of MB in all experiments. The effects were largest in the svOCT imaging mode, and uniformly diminished with increasing flow velocity. These findings suggest the feasibility of utilizing MB for tissue hemodynamic investigations and for microvasculature contrast enhancement in OCT angiography.

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          Author and article information

          Journal
          J Biomed Opt
          Journal of biomedical optics
          SPIE-Intl Soc Optical Eng
          1560-2281
          1083-3668
          July 01 2016
          : 21
          : 7
          Affiliations
          [1 ] Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.
          [2 ] University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, Canada.
          [3 ] Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, CanadacSt. Michael Hospital, Keenan Research Centre of the LKS Knowledge Institute, 209 Victoria Street, Toronto M5B 1W8, Canada.
          [4 ] University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, CanadadUniversity Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Tor.
          Article
          2541620
          10.1117/1.JBO.21.7.076014
          27533242
          57a96b98-f705-4a9f-885e-43407a25e592
          History

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