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      Primary structure and functional expression from complementary DNA of a brain calcium channel.

      Nature

      Amino Acid Sequence, Animals, Blotting, Northern, Brain, Calcium Channels, genetics, physiology, Cloning, Molecular, DNA, Gene Expression, Microinjections, Molecular Sequence Data, RNA, Messenger, administration & dosage, Rabbits, Tissue Distribution, Xenopus

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          Abstract

          The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

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          Journal
          1849233
          10.1038/350398a0

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