Impact of Platelet Endothelial Aggregation Receptor-1 Genotypes on Platelet Reactivity and Early Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention and Treated With Aspirin and Clopidogrel.

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Abstract

The genetic determinants of response to clopidogrel and aspirin are incompletely characterized. Recently, PEAR1 (platelet endothelial aggregation receptor-1) rs12041331 polymorphism has been shown to influence the platelet reactivity, but its impact on cardiovascular outcomes remains unclear in patients treated with antiplatelet agents.

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Journal

Journal ID (iso-abbrev): Circ Cardiovasc Interv

Title: Circulation. Cardiovascular interventions

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1941-7632

ISSN (Print): 1941-7640

Publication date (Electronic): May 2019

Volume: 12

Issue: 5

Affiliations

[1 ] Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, China (K.X., S.Y., S.Z., M.Y., J.Z., Y.F., L. Ying, X.H., X.Z., C.L.).

[2 ] Department of Cardiology, Shanghai General Hospital, China (K.X.).

[3 ] Department of Cardiology, the Second People's Hospital of Lianyungang, Jiangsu, China (S.Z.).

[4 ] Department of Cardiology, the Affiliated Jiangning Hospital of Nanjing Medical UniversityJiangsu, China (T.Z.).

[5 ] Department of Cardiology, Jining First People's Hospital, Shandong, China (D.K.).

[6 ] Department of Cardiology, People's Hospital of Maanshan City, Anhui, China (J.C.).

[7 ] Department of Cardiology, the Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (L.X.).

[8 ] Department of Cardiology, Fuyang Fifth People's Hospital, Anhui, China (J.L.).

[9 ] Department of Geriatrics, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Jiangsu, China (H.Z.).

[10 ] Department of Cardiology, Xuzhou Children's Hospital, Jiangsu, China (F.W.).

[11 ] Department of Cardiology, Jiangsu Province Official Hospital, Nanjing, China (L. Yang).

[12 ] Department of Cardiology, Huai'an Hospital Affiliated to Xuzhou University, Second People's Hospital of Huai'an City, Jiangsu, China (L. Ying).

[13 ] Department of Cardiology, Jinhua Municipal Central Hospital, Zhejiang, China (X.H.).

[14 ] Department of Cardiology, the Second Affiliated Hospital of Medical School of Southeast University, Nanjing, Jiangsu, China (X.Z.).

[15 ] Thrombosis and Atherosclerosis Research Institute and Department of Medicine (N.C.C.), McMaster University, Hamilton, ON, Canada.

Article

DOI: 10.1161/CIRCINTERVENTIONS.118.007019

PubMed ID: 31018667

SO-VID: 57bfe421-63f3-444d-b8b5-d3ab28fb41de

History

Keywords: diabetes mellitus,asprin,clopidogrel,pharmacogenetics,PEAR1,percutaneous coronary intervention

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Keywords: diabetes mellitus, asprin, clopidogrel, pharmacogenetics, PEAR1, percutaneous coronary intervention

Impact of Platelet Endothelial Aggregation Receptor-1 Genotypes on Platelet Reactivity and Early Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention and Treated With Aspirin and Clopidogrel.

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Cardiovascular Innovations and Applications

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