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      Pharmacologic Approach to the Maintenance of Urate Homeostasis

      Nephron

      S. Karger AG

      Uric acid, Probenecid, Sulfinpyrazone, Allopurinol, Oxipurinol

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          Abstract

          A reduction in the serum urate concentration in hyperuricemic subjects can be achieved by increasing the renal excretion of uric acid, by inhibiting its synthesis, or by a combination of both modalities. The three most commonly used hypouricemic drugs are probenecid, sulfinpyrazone and allopurinol. Each drug has been considered in detail with regard to its mechanism of action, metabolism, diverse metabolic effects, side effects and interaction with other drugs. In addition, guidelines for the use of these drugs in hyperuricemic subjects are proposed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2620-3
          978-3-318-02135-6
          1660-8151
          2235-3186
          1975
          1975
          28 November 2008
          : 14
          : 1
          : 99-115
          Affiliations
          Department of Medicine, Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, N. C.
          Article
          180439 Nephron 1975;14:99–115
          10.1159/000180439
          1091870
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Influence of the Kidney Upon Urate Homeostasis in Man

          Cardiovascular Medicine, Nephrology

          Sulfinpyrazone, Probenecid, Uric acid, Allopurinol, Oxipurinol

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