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      Evaluating epidemic forecasts in an interval format

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          Abstract

          For practical reasons, many forecasts of case, hospitalization, and death counts in the context of the current Coronavirus Disease 2019 (COVID-19) pandemic are issued in the form of central predictive intervals at various levels. This is also the case for the forecasts collected in the COVID-19 Forecast Hub ( https://covid19forecasthub.org/). Forecast evaluation metrics like the logarithmic score, which has been applied in several infectious disease forecasting challenges, are then not available as they require full predictive distributions. This article provides an overview of how established methods for the evaluation of quantile and interval forecasts can be applied to epidemic forecasts in this format. Specifically, we discuss the computation and interpretation of the weighted interval score, which is a proper score that approximates the continuous ranked probability score. It can be interpreted as a generalization of the absolute error to probabilistic forecasts and allows for a decomposition into a measure of sharpness and penalties for over- and underprediction.

          Author summary

          During the COVID-19 pandemic, model-based probabilistic forecasts of case, hospitalization, and death numbers can help to improve situational awareness and guide public health interventions. The COVID-19 Forecast Hub ( https://covid19forecasthub.org/) collects such forecasts from numerous national and international groups. Systematic and statistically sound evaluation of forecasts is an important prerequisite to revise and improve models and to combine different forecasts into ensemble predictions. We provide an intuitive introduction to scoring methods, which are suitable for the interval/quantile-based format used in the Forecast Hub, and compare them to other commonly used performance measures.

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          Most cited references32

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          Strictly Proper Scoring Rules, Prediction, and Estimation

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            Making and Evaluating Point Forecasts

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              Predictive model assessment for count data.

              We discuss tools for the evaluation of probabilistic forecasts and the critique of statistical models for count data. Our proposals include a nonrandomized version of the probability integral transform, marginal calibration diagrams, and proper scoring rules, such as the predictive deviance. In case studies, we critique count regression models for patent data, and assess the predictive performance of Bayesian age-period-cohort models for larynx cancer counts in Germany. The toolbox applies in Bayesian or classical and parametric or nonparametric settings and to any type of ordered discrete outcomes.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS Comput Biol
                PLoS Comput Biol
                plos
                ploscomp
                PLoS Computational Biology
                Public Library of Science (San Francisco, CA USA )
                1553-734X
                1553-7358
                12 February 2021
                February 2021
                : 17
                : 2
                : e1008618
                Affiliations
                [1 ] Chair of Statistics and Econometrics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
                [2 ] Computational Statistics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany
                [3 ] School of Public Health and Health Sciences, Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Massachusetts, United States of America
                [4 ] Institute for Stochastics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
                Yale School of Public Health, UNITED STATES
                Author notes

                The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-3777-1410
                https://orcid.org/0000-0001-9397-3271
                https://orcid.org/0000-0003-3503-9899
                Article
                PCOMPBIOL-D-20-01502
                10.1371/journal.pcbi.1008618
                7880475
                33577550
                57d37b3a-9143-4910-806f-4c9c69e02fbe
                © 2021 Bracher et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Page count
                Figures: 6, Tables: 0, Pages: 15
                Funding
                The work of JB was supported by the Helmholtz Foundation via the SIMCARD Information & Data Science Pilot Project. TG is grateful for support by the Klaus Tschira Foundation. ER and NR were supported by the US Centers for Disease Control and Prevention (1U01IP001122). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Perspective
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Viral Diseases
                Covid 19
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Forecasting
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Forecasting
                Medicine and Health Sciences
                Public and Occupational Health
                Medicine and Health Sciences
                Epidemiology
                Pandemics
                Medicine and Health Sciences
                Epidemiology
                Physical Sciences
                Mathematics
                Algebra
                Polynomials
                Binomials
                Medicine and Health Sciences
                Epidemiology
                Epidemiological Methods and Statistics
                People and places
                Geographical locations
                North America
                United States

                Quantitative & Systems biology
                Quantitative & Systems biology

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