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      Adult respiratory distress syndrome: evidence of early fibrogenesis and absence of glucocorticoid receptors.

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          Abstract

          In five lung biopsies from patients who developed the clinical picture of Adult Respiratory Distress Syndrome (ARDS) after cardiopulmonary bypass the pulmonary alterations were studied morphologically and glucocorticoid receptors determined. The time between cardiac surgery and pulmonary biopsy was 4-7 days. The results showed severe pulmonary lesions, with marked endothelial damage and active collagen secretion in the pulmonary interstitium, along the capillary bed. The glucocorticoid receptor level of the lungs with ARDS was 4.7 +/- 7.04 fmol/mg protein (control 4.28 +/- 4.32 fmol/mg protein). The results indicate that the process of collagen secretion may begin in the early phase of ARDS and that the benefits of glucocorticoid therapy in the management of ARDS should be reassessed.

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          Author and article information

          Journal
          Eur J Respir Dis
          European journal of respiratory diseases
          0106-4339
          0106-4339
          Oct 1986
          : 69
          : 4
          Article
          3817060
          57dcaca8-a11f-4b94-bd2b-c1dd0002e304
          History

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