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      Hypothalamic GnRH Pulse Generator Activity during the Estradiol-lnduced LH Surge in Ovariectomized Goats

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          Abstract

          Electrophysiological manifestation of the hypothalamic GnRH pulse generator activity was examined during the LH surge induced by estradiol in ovariectomized goats. The characteristic increases in the frequency of multiple unit activity (MUA volley) associated with the pulsatile secretion of LH were recorded using electrodes implanted bilaterally in the medial basal hypothalamus. Estradiol was infused for 16 h at the rate of 3 µg/h, to induce an LH surge 10.0–11.5 h later. Regular recurrence of MUA volley was observed throughout the experimental period including the LH surge, but the interval between the MUA volleys became longer (p < 0.01) after the onset of the LH surge as compared with the pretreatment control period (32.9 ± 2.1 vs. 60.0 ± 5.1 min). These results suggest that an increased frequency of LH pulses is not a prerequisite for the LH surge in ovariectomized goats given estradiol, and imply that the positive feedback effects of estradiol on LH secretion appear to be exerted through a neuronal mechanism that is intrinsically different from the GnRH pulse generator.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 56
          : 5
          : 641-645
          Affiliations
          aLaboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology; bLaboratory of Veterinary Ethology, University of Tokyo, Tokyo, Japan
          Article
          126287 Neuroendocrinology 1992;56:641–645
          10.1159/000126287
          1488096
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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