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DARPP-32 binds to tra2-beta1 and influences alternative splicing
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Abstract
The majority of human genes undergo alternative splicing, which is frequently altered
in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein,
32kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32
binds directly to the splicing factor tra2-beta1 (transformer 2). DARPP-32 changes
the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner,
suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling
pathways and pre-mRNA processing.