Blog
About

98
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Adaptive Immune Features of Natural Killer Cells

      , ,

      Nature

      Ly49H, DAP12, m157, interferon-gamma, NK1.1

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In an adaptive immune response, naïve T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion following re-encounter with the same pathogen. Although Natural Killer cells traditionally have been classified as cells of the innate immune system, they share many similarities with cytotoxic T lymphocytes. In a mouse model of cytomegalovirus (MCMV) infection, we demonstrate that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1000-fold in the liver following infection. Following a contraction phase, Ly49H + NK cells reside in lymphoid and non-lymphoid organs for several months. These self-renewing “memory” NK cells rapidly degranulate and produce cytokines upon reactivation. Adoptive transfer of these NK cells into naïve animals followed by viral challenge results in a robust secondary expansion and protective immunity. These findings reveal novel properties of NK cells previously attributed only to cells of the adaptive immune system.

          Related collections

          Most cited references 36

          • Record: found
          • Abstract: found
          • Article: not found

          NK cell recognition.

          The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Preferential localization of effector memory cells in nonlymphoid tissue.

            Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

              Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority of the responding T cells has not been defined. To address this issue we used tetramers of MHC class I molecules containing viral peptides to directly visualize antigen-specific CD8 T cells during acute LCMV infection of mice. Based on tetramer binding and two sensitive assays measuring interferon-gamma production at the single-cell level, we found that 50%-70% of the activated CD8 T cells were LCMV specific [2 x 10(7) virus-specific cells/spleen]. Following viral clearance, antigen-specific CD8 T cell numbers dropped to 10(6) per spleen and were maintained at this level for the life of the mouse. Upon rechallenge with LCMV, there was rapid expansion of memory T cells, but after infection with the heterologous vaccinia virus there was no detectable change in the numbers of LCMV-specific memory CTL. Therefore, much of the CD8 T cell expansion seen during viral infection represents antigen-specific cells and warrants a revision of our current thinking on the size of the antiviral response.
                Bookmark

                Author and article information

                Journal
                0410462
                6011
                Nature
                Nature
                0028-0836
                1476-4687
                17 March 2009
                11 January 2009
                29 January 2009
                28 July 2009
                : 457
                : 7229
                : 557-561
                Affiliations
                Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143
                Author notes
                Reprints and permissions information is available at www.nature.com/reprints. The authors have no conflicting financial interests. Correspondence and requests for materials should be addressed to L.L.L. ( lewis.lanier@ 123456ucsf.edu )
                Article
                nihpa102772
                10.1038/nature07665
                2674434
                19136945
                Funding
                Funded by: National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
                Award ID: R01 AI068129-09 ||AI
                Categories
                Article

                Uncategorized

                m157, nk1.1, ly49h, dap12, interferon-gamma

                Comments

                Comment on this article