miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

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Abstract

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this disease. Recently, there is increasing evidence that circulating miRNAs (miRNAs), i.e. endogenous, stable, single-stranded, short, non-coding RNAs, can be used as diagnostic biomarkers for CVD. Furthermore, miRNAs represent potential novel therapeutic targets for several cardiovascular disorders. In this review we provides an overview of the effects of several CVD; including heart failure, acute myocardial infarction, arrhythmias and pulmonary hypertension; on levels of circulating miRNAs. In addition, the use of miRNA as therapeutic targets is also discussed, as well as challenges and recommendations in their use in the diagnosis of CVD.

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Author and article information

Contributors

Jonathan H Freedman: jonathan.freedman@louisville.edu

Yang Zheng: zhengyang@jlu.edu.cn

Journal

Journal ID (nlm-ta): Acta Pharmacol Sin

Journal ID (iso-abbrev): Acta Pharmacol. Sin

Title: Acta Pharmacologica Sinica

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 1671-4083

ISSN (Electronic): 1745-7254

Publication date (Electronic): 7 June 2018

Publication date (Print): July 2018

Volume: 39

Issue: 7

Pages: 1073-1084

Affiliations

[1 ]GRID grid.430605.4, The Center of Cardiovascular Diseases, , the First Hospital of Jilin University, ; Changchun, 130021 China

[2 ]ISNI 0000 0001 2113 1622, GRID grid.266623.5, Pediatric Research Institute, , the Department of Pediatrics of University of Louisville, ; Louisville, 40202 USA

[3 ]Endoscopy Center China-Japan Union Hospital of Jilin University, 126 Xiantai Street, 130033 Changchun, China

[4 ]ISNI 0000 0001 2113 1622, GRID grid.266623.5, Department of Pharmacology and Toxicology, , the University of Louisville, ; 40202 Louisville, USA

Article

Publisher ID: 101

DOI: 10.1038/aps.2018.30

PMC ID: 6289363

PubMed ID: 29877320

SO-VID: 57fbb972-a7b8-461c-b89d-7199c6e065e2

License:

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/