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      Inflammatory mechanisms in ischemic stroke: role of inflammatory cells.

      1 , ,
      Journal of leukocyte biology
      Society for Leukocyte Biology

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          Abstract

          Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms of ischemic brain injury. Experimentally and clinically, the brain responds to ischemic injury with an acute and prolonged inflammatory process, characterized by rapid activation of resident cells (mainly microglia), production of proinflammatory mediators, and infiltration of various types of inflammatory cells (including neutrophils, different subtypes of T cells, monocyte/macrophages, and other cells) into the ischemic brain tissue. These cellular events collaboratively contribute to ischemic brain injury. Despite intense investigation, there are still numerous controversies concerning the time course of the recruitment of inflammatory cells in the brain and their pathogenic roles in ischemic brain injury. In this review, we provide an overview of the time-dependent recruitment of different inflammatory cells following focal cerebral I/R. We discuss how these cells contribute to ischemic brain injury and highlight certain recent findings and currently unanswered questions about inflammatory cells in the pathophysiology of ischemic stroke.

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          Author and article information

          Journal
          J Leukoc Biol
          Journal of leukocyte biology
          Society for Leukocyte Biology
          1938-3673
          0741-5400
          May 2010
          : 87
          : 5
          Affiliations
          [1 ] Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.
          Article
          jlb.1109766
          10.1189/jlb.1109766
          2858674
          20130219
          57fd448c-3be1-4e4e-b21c-8b9875e178a4
          History

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