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      Review of patient decision-making factors and attitudes regarding preimplantation genetic diagnosis.

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          Abstract

          The increasing technical complexity and evolving options for repro-genetic testing have direct implications for information processing and decision making, yet the research among patients considering preimplantation genetic diagnosis (PGD) is narrowly focused. This review synthesizes the literature regarding patient PGD decision-making factors, and illuminates gaps for future research and clinical translation. Twenty-five articles met the inclusion criteria for evaluating experiences and attitudes of patients directly involved in PGD as an intervention or considering using PGD. Thirteen reports were focused exclusively on a specific disease or condition. Five themes emerged: (1) patients motivated by prospects of a healthy, genetic-variant-free child, (2) PGD requires a commitment of time, money, energy and emotions, (3) patients concerned about logistics and ethics of discarding embryos, (4) some patients feel sense of responsibility to use available technologies, and (5) PGD decisions are complex for individuals and couples. Patient research on PGD decision-making processes has very infrequently used validated instruments, and the data collected through both quantitative and qualitative designs have been inconsistent. Future research for improving clinical counseling is needed to fill many gaps remaining in the literature regarding this decision-making process, and suggestions are offered.

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          Author and article information

          Journal
          Clin. Genet.
          Clinical genetics
          Wiley
          1399-0004
          0009-9163
          July 2018
          : 94
          : 1
          Affiliations
          [1 ] Department of Psychology, The New School for Social Research, New York, NY.
          [2 ] Department of Psychology, Stony Brook University, Stony Brook, NY.
          [3 ] Reproductive Specialists of NY, Stony Brook, NY.
          [4 ] Department of Obstetrics, Gynecology and Reproductive Medicine, Stony Brook Medicine, Stony Brook University, Stony Brook, NY.
          Article
          10.1111/cge.13174
          29120067
          580b86d7-5c55-45f2-9e96-fdfad6f172b5
          History

          health attitudes,ethics,genetic counseling,knowledge,practice,preimplantation genetic diagnosis,psychology,reproductive endocrinology and infertility,decision making,PGD

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