9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      The relative role of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in coronary artery disease: evidence from large-scale statin and fibrate trials

      The American Journal of Cardiology
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Statin therapy has been remarkably successful in reducing coronary events and improving survival. Reduction in low-density lipoprotein cholesterol (LDL-C) is the paramount mechanism for the benefit of statins. Although the relation between reduction of risk of coronary artery disease and pretreatment lipid levels has not been fully resolved, a feature of statin therapy emerging from previous large-scale trials is the diminished benefit when the baseline level of LDL-C is low (eg, <125 mg/dL). Increases in levels of high-density lipoprotein cholesterol (HDL-C) with statin therapy are associated with mild reductions in coronary events, indicating that HDL-C is an important element. However, the risk of low HDL-C is not altered by statin therapy, in marked contrast with LDL-C. Because most coronary events have not been prevented in the statin trials, nonstatin lipid therapy, including fibrates, may be necessary to further reduce the unacceptably high rate of coronary artery disease.

          Related collections

          Author and article information

          Journal
          The American Journal of Cardiology
          The American Journal of Cardiology
          Elsevier BV
          00029149
          December 2001
          December 2001
          : 88
          : 12
          : 14-18
          Article
          10.1016/S0002-9149(01)02147-6
          11788125
          58192ae7-a9ba-48fe-9760-b68b3cdcfacc
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article