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      Structural and functional papez circuit integrity in amyotrophic lateral sclerosis.

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          Abstract

          Cognitive impairment in amyotrophic lateral sclerosis (ALS) is heterogeneous but now recognized as a feature in non-demented patients and no longer exclusively attributed to executive dysfunction. However, despite common reports of temporal lobe changes and memory deficits in ALS, episodic memory has been less explored. In the current study, we examined how the Papez circuit-a circuit known to participate in memory processes-is structurally and functionally affected in ALS patients (n = 20) compared with healthy controls (n = 15), and whether these changes correlated with a commonly used clinical measure of episodic memory. Our multimodal MRI approach (cortical volume, voxel-based morphometry, diffusion tensor imaging and resting state functional magnetic resonance) showed reduced gray matter in left hippocampus, left entorhinal cortex and right posterior cingulate as well as increased white matter fractional anisotropy and decreased mean diffusivity in the left cingulum bundle (hippocampal part) of ALS patients compared with controls. Interestingly, thalamus, mammillary bodies and fornix were preserved. Finally, we report a decreased functional connectivity in ALS patients in bilateral hippocampus, bilateral anterior and posterior parahippocampal gyrus and posterior cingulate. The results revealed that ALS patients showed statistically significant structural changes, but more important, widespread prominent functional connectivity abnormalities across the regions comprising the Papez circuit. The decreased functional connectivity found in the Papez network may suggest these changes could be used to assess risk or assist early detection or development of memory symptoms in ALS patients even before structural changes are established.

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          Author and article information

          Journal
          Brain Imaging Behav
          Brain imaging and behavior
          Springer Nature America, Inc
          1931-7565
          1931-7557
          Jan 27 2018
          Affiliations
          [1 ] Center of Mathematics, Computation and Cognition, Universidade Federal do ABC, Santo André, Brazil.
          [2 ] Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, James Watson Road, Norwich, Norfolk, NR4 7TJ, UK.
          [3 ] School of Health Sciences, Norwich Medical School, University of East Anglia, Norwich, UK.
          [4 ] Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
          [5 ] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
          [6 ] Brain & Mind Centre and Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
          [7 ] Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
          [8 ] Department of Medicine, Norwich Medical School, University of East Anglia, Norwich Research Park, James Watson Road, Norwich, Norfolk, NR4 7TJ, UK. m.hornberger@uea.ac.uk.
          Article
          10.1007/s11682-018-9825-0
          10.1007/s11682-018-9825-0
          29374846
          581bbff3-e139-44da-bcd7-3202e51cd840

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