We give a detailed presentation of a recently proposed mechanism of generating the energy scale of inflation by loop effects in quantum cosmology. We discuss the quantum origin of the early inflationary Universe from the no-boundary and tunneling quantum states and present a universal effective action algorithm for the distribution function of chaotic inflationary cosmologies in both of these states. The energy scale of inflation is calculated by finding a sharp probability peak in this distribution function for a tunneling model driven by the inflaton field with large negative constant \(\xi\) of non-minimal interaction. The sub-Planckian parameters of this peak (the mean value of the corresponding Hubble constant \(H\simeq 10^{-5}m_P\), its quantum width \(\Delta H/H\simeq 10^{-5}\) and the number of inflationary e-foldings \(N\geq 60\)) are found to be in good correspondence with the observational status of inflation theory, provided the coupling constants of the theory are constrained by a condition which is likely to be enforced by the (quasi) supersymmetric nature of the sub-Planckian particle physics model.