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      Anti-Gonadotropic and Anti-Growth Effects of the Pineal Gland in Immature Female Rats

      , ,

      Neuroendocrinology

      S. Karger AG

      Pineal gland, Growth, Sexual maturation, Puberty, Light deprivation

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          Abstract

          The effects of constant darkness, pinealectomy, and heterotopic pineal transplantation on the increase in body weight and on sexual maturation were studied in prepuberal female rats. Animals on restricted food intake served as additional controls. caused a subnormal increase in body weight, subnormal ovarian weight at puberty, and in some but not all Light conditions experiments delayed vaginal opening. All these effects seemed to be dependent on the presence of an in situ pineal gland. Observations on animals on a restricted food intake and data on animals varying spontaneously in body weight increase indicated that a smaller body weight increase causes a delay of vaginal opening but not a subnormal ovarian weight at puberty. It is argued that, in maturing animals, the anti-gonadotrophic and anti-growth influences of the pineal gland are separate physiological mechanisms.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 10
          : 2
          : 121-128
          Affiliations
          Department of Anatomy, Medical Faculty, Rotterdam
          Article
          122084 Neuroendocrinology 1972;10:121–128
          10.1159/000122084
          5065391
          © 1972 S. Karger AG, Basel

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          Page count
          Pages: 8
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