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Sex-related differences and thyroid hormone regulation of vasoactive intestinal peptide gene expression in the rat brain and pituitary
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Abstract
To determine the effects of hypothyroidism and sexual dimorphism on the gene expression
of vasoactive intestinal peptide (VIP) in the rat brain, VIP mRNA levels were measured
in the cerebral cortex, hypothalamus and anterior pituitary of control and hypothyroid
(thionamide-treated) rats. A tissue-specific increase in VIP mRNA level was observed
in the hypothyroid pituitary. In addition, higher levels of VIP mRNA were found in
the pituitaries of male rats suggesting a sex-related difference in VIP gene expression.
Similar differences were not observed in the cortex or hypothalamus.